Change of the melanocortin system caused by bilateral subthalamic nucleus stimulation in Parkinson’s disease
Identifieur interne : 000369 ( Main/Exploration ); précédent : 000368; suivant : 000370Change of the melanocortin system caused by bilateral subthalamic nucleus stimulation in Parkinson’s disease
Auteurs : F. Escamilla-Sevilla ; M. J. Pérez-Navarro ; M. Mu Oz-Pasadas ; C. Sáez-Zea ; M. Jouma-Katati ; G. Piédrola-Maroto ; A. Ramírez-Navarro [Espagne] ; A. Mínguez-CastellanosSource :
- Acta Neurologica Scandinavica [ 0001-6314 ] ; 2011-10.
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Abstract
Escamilla‐Sevilla F, Pérez‐Navarro MJ, Muñoz‐Pasadas M, Sáez‐Zea C, Jouma‐Katati M, Piédrola‐Maroto G, Ramírez‐Navarro A, Mínguez‐Castellanos A. Change of the melanocortin system caused by bilateral subthalamic nucleus stimulation in Parkinson’s disease.
Acta Neurol Scand: 2011: 124: 275–281.
© 2011 John Wiley & Sons A/S. Objectives – Determine whether bilateral subthalamic nucleus stimulation (STN–DBS) in Parkinson’s disease (PD) is associated with an increase in neuropeptide Y (NPY) and/or resistance to inhibition by leptin in relation to post‐surgery weight gain. Materials and Methods – This prospective study included 20 patients who underwent bilateral STN–DBS and 17 who refused surgery. Data were obtained at baseline, 3 and 6 months on neurological and nutritional status, including determination of body mass index (BMI) and serum NPY and leptin levels. Results – NPY and leptin levels changed over time, with a distinct pattern. The BMI increase at 6 months was greater in the surgical group (5.5 ± 6.3% vs 0.5 ± 3.5%; P = 0.035). Medical group exhibited a reduction in leptin level (−2.0 ± 4.3 ng/ml) and a consequent increase in NPY level (72.4 ± 58.7 pmol/ml). However, STN–DBS patients showed an increase in leptin (3.1 ± 5.0 ng/ml; P = 0.001 vs medical group) and also in NPY (12.1 ± 53.6 pmol/ml; P = 0.022 vs medical group) levels, which suggests resistance to inhibition by leptin. Rise in NPY level correlated with higher stimulation voltages. Conclusions – Bilateral STN–DBS causes disruption of the melanocortin system, probably related to diffusion of the electric current to the hypothalamus. This mechanism may in part explain the weight gain of patients with PD after surgery.
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DOI: 10.1111/j.1600-0404.2010.01469.x
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Change of the melanocortin system caused by bilateral subthalamic nucleus stimulation in Parkinson’s disease.
Acta Neurol Scand: 2011: 124: 275–281.
© 2011 John Wiley & Sons A/S. Objectives – Determine whether bilateral subthalamic nucleus stimulation (STN–DBS) in Parkinson’s disease (PD) is associated with an increase in neuropeptide Y (NPY) and/or resistance to inhibition by leptin in relation to post‐surgery weight gain. Materials and Methods – This prospective study included 20 patients who underwent bilateral STN–DBS and 17 who refused surgery. Data were obtained at baseline, 3 and 6 months on neurological and nutritional status, including determination of body mass index (BMI) and serum NPY and leptin levels. Results – NPY and leptin levels changed over time, with a distinct pattern. The BMI increase at 6 months was greater in the surgical group (5.5 ± 6.3% vs 0.5 ± 3.5%; P = 0.035). Medical group exhibited a reduction in leptin level (−2.0 ± 4.3 ng/ml) and a consequent increase in NPY level (72.4 ± 58.7 pmol/ml). However, STN–DBS patients showed an increase in leptin (3.1 ± 5.0 ng/ml; P = 0.001 vs medical group) and also in NPY (12.1 ± 53.6 pmol/ml; P = 0.022 vs medical group) levels, which suggests resistance to inhibition by leptin. Rise in NPY level correlated with higher stimulation voltages. Conclusions – Bilateral STN–DBS causes disruption of the melanocortin system, probably related to diffusion of the electric current to the hypothalamus. This mechanism may in part explain the weight gain of patients with PD after surgery.</div></front></TEI><affiliations><list><country><li>Espagne</li></country></list><tree><noCountry><name sortKey="Escamilla Evilla, F" sort="Escamilla Evilla, F" uniqKey="Escamilla Evilla F" first="F." last="Escamilla-Sevilla">F. Escamilla-Sevilla</name><name sortKey="Jouma Atati, M" sort="Jouma Atati, M" uniqKey="Jouma Atati M" first="M." last="Jouma-Katati">M. Jouma-Katati</name><name sortKey="Minguez Astellanos, A" sort="Minguez Astellanos, A" uniqKey="Minguez Astellanos A" first="A." last="Mínguez-Castellanos">A. Mínguez-Castellanos</name><name sortKey="Mu Oz Asadas, M" sort="Mu Oz Asadas, M" uniqKey="Mu Oz Asadas M" first="M." last="Mu Oz-Pasadas">M. Mu Oz-Pasadas</name><name sortKey="Perez Avarro, M J" sort="Perez Avarro, M J" uniqKey="Perez Avarro M" first="M. J." last="Pérez-Navarro">M. J. Pérez-Navarro</name><name sortKey="Piedrola Aroto, G" sort="Piedrola Aroto, G" uniqKey="Piedrola Aroto G" first="G." last="Piédrola-Maroto">G. Piédrola-Maroto</name><name sortKey="Saez Ea, C" sort="Saez Ea, C" uniqKey="Saez Ea C" first="C." last="Sáez-Zea">C. Sáez-Zea</name></noCountry><country name="Espagne"><noRegion><name sortKey="Ramirez Avarro, A" sort="Ramirez Avarro, A" uniqKey="Ramirez Avarro A" first="A." last="Ramírez-Navarro">A. Ramírez-Navarro</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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